Publications Writer
2025
Schreiber, R., Ousingsawat, J., and Kunzelmann, K. (2025) Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes. Frontiers in immunology 16, 1562871
Ousingsawat, J., Talbi, K., Gómez-Martín, H., Koy, A., Fernández-Jaén, A., Tekgül, H., Serdaroğlu, E., Ortigoza-Escobar, J. D., Schreiber, R., and Kunzelmann, K. (2025) Dystonia caused by ANO3 variants is due to attenuated Ca(2+) influx by ORAI1. BMC medicine 23, 12
2024
Schreiber, R., Ousingsawat, J., and Kunzelmann, K. (2024) The anoctamins: Structure and function. Cell calcium 120, 102885
Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2024) Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies. International journal of molecularsciences25, 9998
Ousingsawat, J., Centeio, R., Schreiber, R., and Kunzelmann, K. (2024) Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract. Pflugers Archiv : European journal of physiology 476, 211-227
Ousingsawat, J., Centeio, R., Reyne, N., McCarron, A., Cmielewski, P., Schreiber, R., diStefano, G., Römermann, D., Seidler, U., Donnelley, M., and Kunzelmann, K. (2024) Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine. Scientific reports 14, 1464
Kunzelmann, K., Ousingsawat, J., and Schreiber, R. (2024) VSI: The anoctamins: Structure and function: "Intracellular" anoctamins. Cell calcium 120, 102888
2023
Talbi, K., Ousingsawat, J., Centeio, R., Schreiber, R., and Kunzelmann, K. (2023) KCNE1 does not shift TMEM16A from a Ca(2+) dependent to a voltage dependent Cl(-) channel and is not expressed in renal proximal tubule. Pflugers Archiv : European journal of physiology 475, 995-1007
Schreiber, R., Talbi, K., Ousingsawat, J., and Kunzelmann, K. (2023) A TMEM16J variant leads to dysregulated cytosolic calcium which may lead to renal disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37, e22683
Salari, A., Xiu, R., Amiri, M., Pallenberg, S. T., Schreiber, R., Dittrich, A.-M., Tümmler, B., Kunzelmann, K., and Seidler, U. (2023) The Anion Channel TMEM16a/Ano1 Modulates CFTR Activity, but Does Not Function as an Apical Anion Channel in Colonic Epithelium from Cystic Fibrosis Patients and Healthy Individuals. International journal of molecular sciences 24, 14214
Ousingsawat, J., Talbi, K., Gómez-Martín, H., Koy, A., Fernández-Jaén, A., Tekgül, H., Serdaroğlu, E., Schreiber, R., Ortigoza-Escobar, J. D., and Kunzelmann, K. (2023) Broadening the clinical spectrum: molecular mechanisms and new phenotypes of ANO3-dystonia. Brain 147,1982-1995
Kunzelmann, K., Ousingsawat, J., Kraus, A., Park, J. H., Marquardt, T., Schreiber, R., and Buchholz, B. (2023) Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins. International journal of molecular sciences 24, 13278
Kunzelmann, K., Centeio, R., Ousingsawat, J., Talbi, K., Seidler, U., and Schreiber, R. (2023) SLC26A9 in airways and intestine: secretion or absorption? Channels (Austin, Tex.) 17, 2186434
Centeio, R., Cabrita, I., Schreiber, R., and Kunzelmann, K. (2023) TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium. Frontiers in physiology 14, 1157704
2022
Schreiber, R., Cabrita, I., and Kunzelmann, K. (2022) Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f. Gastro Hep Advances 1, 1088-1098
Pinto, M. C., Botelho, H. M., Silva, I. A. L., Railean, V., Neumann, B., Pepperkok, R., Schreiber, R., Kunzelmann, K., and Amaral, M. D. (2022) Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis. Journal of molecular biology, 434, 167436
Ousingsawat, J., Centeio, R., Schreiber, R., and Kunzelmann, K. (2022) Expression of SLC26A9 in Airways and Its Potential Role in Asthma. International journal of molecular sciences 23, 2998
Ousingsawat, J., Centeio, R., Cabrita, I., Talbi, K., Zimmer, O., Graf, M., Göpferich, A., Schreiber, R., and Kunzelmann, K. (2022) Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway Disease. International journal of molecular sciences 23, 1085
Lin, J., Gettings, S. M., Talbi, K., Schreiber, R., Taggart, M. J., Preller, M., Kunzelmann, K., Althaus, M., and Gray, M. A. (2022) Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels. Pflugers Archiv : European journal of physiology 475, 167-179
Leitzke, S., Seidel, J., Ahrens, B., Schreiber, R., Kunzelmann, K., Sperrhacke, M., Bhakdi, S., and Reiss, K. (2022) Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function. Membranes 12, 123
Jo, S., Centeio, R., Park, J., Ousingsawat, J., Jeon, D. K., Talbi, K., Schreiber, R., Ryu, K., Kahlenberg, K., Somoza, V., Delpiano, L., Gray, M. A., Amaral, M. D., Railean, V., Beekman, J. M., Rodenburg, L. W., Namkung, W., and Kunzelmann, K. (2022) The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36, e22534
2021
Talbi, K., Ousingsawat, J., Centeio, R., Schreiber, R., and Kunzelmann, K. (2021) Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells. Membranes11, 723
Talbi, K., Cabrita, I., Schreiber, R., and Kunzelmann, K. (2021) Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca(2+) Signals. International journal of molecular sciences 22, 6019
Talbi, K., Cabrita, I., Kraus, A., Hofmann, S., Skoczynski, K., Kunzelmann, K., Buchholz, B., and Schreiber, R. (2021) The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35, e21897
Prüschenk, S., Majer, M., Schreiber, R., and Schlossmann, J. (2021) IRAG2 Interacts with IP3-Receptor Types 1, 2, and 3 and Regulates Intracellular Ca2+ in Murine Pancreatic Acinar Cells. International journal of molecular sciences 22, 13409
Ousingsawat, J., Schreiber, R., Gulbins, E., Kamler, M., and Kunzelmann, K. (2021) P. aeruginosa Induced Lipid Peroxidation Causes Ferroptotic Cell Death in Airways. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 55, 590-604
Centeio, R., Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2021) CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A. International journal of molecular sciences 22, 5133
Centeio, R., Ousingsawat, J., Cabrita, I., Schreiber, R., Talbi, K., Benedetto, R., Doušová, T., Verbeken, E. K., De Boeck, K., Cohen, I., and Kunzelmann, K. (2021) Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease. International journal of molecular sciences 22, 7852
Cabrita, I., Talbi, K., Kunzelmann, K., and Schreiber, R. (2021) Loss of PKD1 and PKD2 share common effects on intracellular Ca(2+) signalling. Cell calcium 97, 102413
Cabrita, I., Benedetto, R., Wanitchakool, P., Lerias, J., Centeio, R., Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2021) TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells. American journal of respiratory cell and molecular biology 64, 50-58
Berg, P., Svendsen, S. L., Sorensen, M. V., Schreiber, R., Kunzelmann, K., and Leipziger, J. (2021) The molecular mechanism of CFTR- and secretin-dependent renal bicarbonate excretion. The Journal of physiology 99, 3003-3011
2020
Schreiber, R., Ousingsawat, J., and Kunzelmann, K. (2020) Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signalling. International journal of molecularsciences21, 4065
Pinto, M. C., Schreiber, R., Lerias, J., Ousingsawat, J., Duarte, A., Amaral, M., and Kunzelmann, K. (2020) Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation. Cells 9, 1138
Park, J. H., Ousingsawat, J., Cabrita, I., Bettels, R. E., Große-Onnebrink, J., Schmalstieg, C., Biskup, S., Reunert, J., Rust, S., Schreiber, R., Kunzelmann, K., and Marquardt, T. (2020) TMEM16A deficiency: a potentially fatal neonatal disease resulting from impaired chloride currents. Journal of medical genetics 58, 247-253
Ormel, L., Lauritzen, K. H., Schreiber, R., Kunzelmann, K., and Gundersen, V. (2020) GABA, but Not Bestrophin-1, Is Localised in Astroglial Processes in the Mouse Hippocampus and the Cerebellum. Frontiers in molecular neuroscience 13, 135
Centeio, R., Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2020) Ca(2+) Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl(-) Channels. Frontiers in cell and developmental biology 8, 596879
Centeio, R., Cabrita, I., Benedetto, R., Talbi, K., Ousingsawat, J., Schreiber, R., Sullivan, J. K., and Kunzelmann, K. (2020) Pharmacological Inhibition and Activation of the Ca(2+) Activated Cl(-) Channel TMEM16A. International journal of molecular sciences 21, 2557
Cabrita, I., Kraus, A., Scholz, J. K., Skoczynski, K., Schreiber, R., Kunzelmann, K., and Buchholz, B. (2020) Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo. Nature communications 11, 4320
Cabrita, I., Buchholz, B., Schreiber, R., and Kunzelmann, K. (2020) TMEM16A drives renal cyst growth by augmenting Ca(2+) signalling in M1 cells. Journal of molecular medicine 98, 659-671
Berg, P., Svendsen, S. L., Sorensen, M. V., Larsen, C. K., Andersen, J. F., Jensen-Fangel, S., Jeppesen, M., Schreiber, R., Cabrita, I., Kunzelmann, K., and Leipziger, J. (2020) Impaired Renal HCO(3) (-) Excretion in Cystic Fibrosis. Journal of the American Society of Nephrology : JASN 31, 1711-1727
Benedetto, R., Centeio, R., Ousingsawat, J., Schreiber, R., Janda, M., and Kunzelmann, K. (2020) Transport properties in CFTR-/- knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na(+) absorption. Pflugers Archiv : European journal of physiology 472, 1507-1519
2019
Schreiber, R., Buchholz, B., Kraus, A., Schley, G., Scholz, J., Ousingsawat, J., and Kunzelmann, K. (2019) Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. Journal of the American Society of Nephrology : JASN 30, 228-242
Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2019) TMEM16F/Anoctamine 6 in Ferroptotic Cell Death. Cancers 11, 625
Kunzelmann, K., Ousingsawat, J., Cabrita, I., Dousova, T., Bahr, A., Janda, M., Schreiber, R., and Benedetto, R. (2019) TMEM16A in Cystic Fibrosis: Activating or Inhibiting? Frontiers in pharmacology 10, 3
Kunzelmann, K., Ousingsawat, J., Benedetto, R., Cabrita, I., and Schreiber, R. (2019) Contribution of Anoctamins to Cell Survival and Cell Death. Cancers 11, 382
Kunzelmann, K., Centeio, R., Wanitchakool, P., Cabrita, I., Benedetto, R., Saha, T., Hoque, K. M., and Schreiber, R. (2019) Control of Ion Transport by Tmem16a Expressed in Murine Intestine. Frontiers inphysiology10, 1262
Cabrita, I., Benedetto, R., Schreiber, R., and Kunzelmann, K. (2019) Niclosamide repurposed for the treatment of inflammatory airway disease. JCI insight 4, e128414
Benedetto, R., Ousingsawat, J., Cabrita, I., Pinto, M., Lerias, J. R., Wanitchakool, P., Schreiber, R., and Kunzelmann, K. (2019) Plasma membrane-localised TMEM16 proteins are indispensable for expression of CFTR. Journal of molecular medicine 97, 711-722
Benedetto, R., Cabrita, I., Schreiber, R., and Kunzelmann, K. (2019) TMEM16A is indispensable for basal mucus secretion in airways and intestine. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33, 4502-4512
2018
Veit, M., Koyro, K. I., Ahrens, B., Bleibaum, F., Munz, M., Rövekamp, H., Andrä, J., Schreiber, R., Kunzelmann, K., Sommer, A., Bhakdi, S., and Reiss, K. (2018) Anoctamin-6 regulates ADAM sheddase function. Biochimica et biophysica acta. Molecular cell research 1865, 1598-1610
Schreiber, R., Ousingsawat, J., Wanitchakool, P., Sirianant, L., Benedetto, R., Reiss, K., and Kunzelmann, K. (2018) Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca(2+) and plasma membrane lipid. The Journal of physiology 596, 217-229
Schenk, L. K., Ousingsawat, J., Skryabin, B. V., Schreiber, R., Pavenstadt, H., and Kunzelmann, K. (2018) Regulation and Function of TMEM16F in Renal Podocytes. International journal of molecularsciences19, 1798
Ousingsawat, J., Wanitchakool, P., Schreiber, R., and Kunzelmann, K. (2018) Contribution of TMEM16F to pyroptotic cell death. Cell death & disease 9, 300
Lérias, J. R., Pinto, M. C., Botelho, H. M., Awatade, N. T., Quaresma, M. C., Silva, I. A. L., Wanitchakool, P., Schreiber, R., Pepperkok, R., Kunzelmann, K., and Amaral, M. D. (2018) A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic. Biochimica et biophysica acta. Molecular cell research 1865, 421-431
Lérias, J., Pinto, M., Benedetto, R., Schreiber, R., Amaral, M., Aureli, M., and Kunzelmann, K. (2018) Compartmentalised crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1. Cellular signalling 44, 10-19
2017
Wanitchakool, P., Ousingsawat, J., Sirianant, L., Cabrita, I., Faria, D., Schreiber, R., and Kunzelmann, K. (2017) Cellular defects by deletion of ANO10 are due to deregulated local calcium signalling. Cellular signalling 30, 41-49
Simoes, F., Ousingsawat, J., Wanitchakool, P., Fonseca, A., Cabrita, I., Benedetto, R., Schreiber, R., and Kunzelmann, K. (2017) CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6). Pflugers Archiv : European journal of physiology 470, 305-314
Ousingsawat, J., Cabrita, I., Wanitchakool, P., Sirianant, L., Krautwald, S., Linkermann, A., Schreiber, R., and Kunzelmann, K. (2017) Ca(2+) signals, cell membrane disintegration, and activation of TMEM16F during necroptosis. Cellular and molecular life sciences :CMLS74, 173-181
Kunzelmann, K., Schreiber, R., and Hadorn, H. B. (2017) Bicarbonate in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 16, 653-662
Cabrita, I., Benedetto, R., Fonseca, A., Wanitchakool, P., Sirianant, L., Skryabin, B. V., Schenk, L. K., Pavenstadt, H., Schreiber, R., and Kunzelmann, K. (2017) Differential effects of anoctamins on intracellular calcium signals. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31, 2123-2134
Benedetto, R., Ousingsawat, J., Wanitchakool, P., Zhang, Y., Holtzman, M. J., Amaral, M., Rock, J. R., Schreiber, R., and Kunzelmann, K. (2017) Epithelial Chloride Transport by CFTR Requires TMEM16A. Scientific reports 7, 12397
2016
Wanitchakool, P., Ousingsawat, J., Sirianant, L., MacAulay, N., Schreiber, R., and Kunzelmann, K. (2016) Cl(-) channels in apoptosis. European biophysics journal : EBJ 45, 599-610
Sirianant, L., Wanitchakool, P., Ousingsawat, J., Benedetto, R., Zormpa, A., Cabrita, I., Schreiber, R., and Kunzelmann, K. (2016) Non-essential contribution of LRRC8A to volume regulation. Pflugers Archiv : European journal of physiology 468, 805-816
Sirianant, L., Ousingsawat, J., Wanitchakool, P., Schreiber, R., and Kunzelmann, K. (2016) Cellular volume regulation by anoctamin 6: Ca(2)(+), phospholipase A2 and osmosensing. Pflugers Archiv : European journal of physiology 468, 335-349
Schreiber, R., and Kunzelmann, K. (2016) Expression of anoctamins in retinal pigment epithelium (RPE). Pflugers Archiv : European journal of physiology 468, 1921-1929
Mattheij, N. J., Braun, A., van Kruchten, R., Castoldi, E., Pircher, J., Baaten, C. C., Wülling, M., Kuijpers, M. J., Köhler, R., Poole, A. W., Schreiber, R., Vortkamp, A., Collins, P. W., Nieswandt, B., Kunzelmann, K., Cosemans, J. M., and Heemskerk, J. W. (2016) Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 30, 727-737
Kunzelmann, K., Cabrita, I., Wanitchakool, P., Ousingsawat, J., Sirianant, L., Benedetto, R., and Schreiber, R. (2016) Modulating Ca(2)(+) signals: a common theme for TMEM16, Ist2, and TMC. Pflugers Archiv : European journal of physiology 468, 475-490
Kraus, A., Schley, G., Kunzelmann, K., Schreiber, R., Peters, D. J., Stadler, R., Eckardt, K. U., and Buchholz, B. (2016) Glucose promotes secretion-dependent renal cyst growth. J Mol Med 94, 107-117
Kraus, A., Grampp, S., Goppelt-Struebe, M., Schreiber, R., Kunzelmann, K., Peters, D. J., Leipziger, J., Schley, G., Schodel, J., Eckardt, K. U., and Buchholz, B. (2016) P2Y2R is a direct target of HIF-1alpha and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 12, 687-695
Benedetto, R., Sirianant, L., Pankonien, I., Wanitchakool, P., Ousingsawat, J., Cabrita, I., Schreiber, R., Amaral, M., and Kunzelmann, K. (2016) Relationship between TMEM16A/anoctamin 1 and LRRC8A. Pflugers Archiv : European journal of physiology 468, 1751-1763
2015
Schreiber, R., Faria, D., Skryabin, B. V., Wanitchakool, P., Rock, J. R., and Kunzelmann, K. (2015) Anoctamins support calcium-dependent chloride secretion by facilitating calcium signalling in adult mouse intestine. Pflugers Archiv : European journal of physiology 467, 1203-1213
Ousingsawat, J., Wanitchakool, P., Schreiber, R., Wuelling, M., Vortkamp, A., and Kunzelmann, K. (2015) Anoctamin-6 controls bone mineralisation by activating the calcium transporter NCX1. The Journal of biological chemistry 290, 6270-6280
Ousingsawat, J., Wanitchakool, P., Kmit, A., Romao, A. M., Jantarajit, W., Schreiber, R., and Kunzelmann, K. (2015) Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. Nature communications 6, 6245
Milenkovic, A., Brandl, C., Milenkovic, V. M., Jendryke, T., Sirianant, L., Wanitchakool, P., Zimmermann, S., Reiff, C. M., Horling, F., Schrewe, H., Schreiber, R., Kunzelmann, K., Wetzel, C. H., and Weber, B. H. (2015) Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells. Proceedings of the National Academy of Sciences of the United States of America 112, E2630-2639
Liu, G., Liu, G., Chen, H., Borst, O., Gawaz, M., Vortkamp, A., Schreiber, R., Kunzelmann, K., and Lang, F. (2015) Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 37, 1934-1944
Hammer, C., Wanitchakool, P., Sirianant, L., Papiol, S., Monnheimer, M., Faria, D., Ousingsawat, J., Schramek, N., Schmitt, C., Margos, G., Michel, A., Kraiczy, P., Pawlita, M., Schreiber, R., Schulz, T. F., Fingerle, V., Tumani, H., Ehrenreich, H., and Kunzelmann, K. (2015) A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity. Molecular medicine (Cambridge, Mass.) 21, 26-37
Forschbach, V., Goppelt-Struebe, M., Kunzelmann, K., Schreiber, R., Piedagnel, R., Kraus, A., Eckardt, K. U., and Buchholz, B. (2015) Anoctamin 6 is localised in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation. Cell death & disease 6, e1899
2014
Weiglmeier, P. R., Berkner, H., Seebahn, A., Vogel, N., Schreiber, R., Wöhrl, B. M., Schwarzinger, S., and Rösch, P. (2014) Prosequence switching: an effective strategy to produce biologically active E. coli heat-stable enterotoxin STh. Journal of biomolecular structure & dynamics 32, 1537-1545
Wanitchakool, P., Wolf, L., Koehl, G. E., Sirianant, L., Schreiber, R., Kulkarni, S., Duvvuri, U., and Kunzelmann, K. (2014) Role of anoctamins in cancer and apoptosis. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 369, 20130096
Sirianant, L., Ousingsawat, J., Tian, Y., Schreiber, R., and Kunzelmann, K. (2014) TMC8 (EVER2) attenuates intracellular signalling by Zn2+ and Ca2+ and suppresses activation of Cl- currents. Cellular signalling 26, 2826-2833
Kunzelmann, K., and Schreiber, R. (2014) Chloride secretion, anoctamin 1 and Ca(2+) signalling. Channels (Austin, Tex.) 8, 387-388
Kunzelmann, K., Nilius, B., Owsianik, G., Schreiber, R., Ousingsawat, J., Sirianant, L., Wanitchakool, P., Bevers, E. M., and Heemskerk, J. W. (2014) Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? Pflugers Archiv : European journal of physiology 466, 407-414
Faria, D., Rock, J. R., Romao, A. M., Schweda, F., Bandulik, S., Witzgall, R., Schlatter, E., Heitzmann, D., Pavenstadt, H., Herrmann, E., Kunzelmann, K., and Schreiber, R. (2014) The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function. Kidney international 85, 1369-1381
Buchholz, B., Schley, G., Faria, D., Kroening, S., Willam, C., Schreiber, R., Klanke, B., Burzlaff, N., Jantsch, J., Kunzelmann, K., and Eckardt, K. U. (2014) Hypoxia-inducible factor-1alpha causes renal cyst expansion through calcium-activated chloride secretion. Journal of the American Society of Nephrology : JASN 25, 465-474
Buchholz, B., Faria, D., Schley, G., Schreiber, R., Eckardt, K. U., and Kunzelmann, K. (2014) Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney international 85, 1058-1067
2013
Tian, Y., Schreiber, R., Wanitchakool, P., Kongsuphol, P., Sousa, M., Uliyakina, I., Palma, M., Faria, D., Traynor-Kaplan, A. E., Fragata, J. I., Amaral, M. D., and Kunzelmann, K. (2013) Control of TMEM16A by INO-4995 and other inositol phosphates. British journal of pharmacology 168, 253-265
Schreiber, R. (2013) Water reabsorption in the kidney, Der Nephrologe 8, 344-347
Kmit, A., van Kruchten, R., Ousingsawat, J., Mattheij, N. J., Senden-Gijsbers, B., Heemskerk, J. W., Schreiber, R., Bevers, E. M., and Kunzelmann, K. (2013) Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell death & disease 4, e611
Almaça, J., Faria, D., Sousa, M., Uliyakina, I., Conrad, C., Sirianant, L., Clarke, L. A., Martins, J. P., Santos, M., Heriché, J. K., Huber, W., Schreiber, R., Pepperkok, R., Kunzelmann, K., and Amaral, M. D. (2013) High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets. Cell 154, 1390-1400
2012
Tian, Y., Schreiber, R., and Kunzelmann, K. (2012) Anoctamins are a family of Ca2+-activated Cl- channels. Journal of cell science 125, 4991-4998
Ruiz, C., Martins, J. R., Rudin, F., Schneider, S., Dietsche, T., Fischer, C. A., Tornillo, L., Terracciano, L. M., Schreiber, R., Bubendorf, L., and Kunzelmann, K. (2012) Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. PloS one 7, e43265
Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2012) Differential contribution of SLC26A9 to Cl(-) conductance in polarised and non-polarised epithelial cells. Journal of cellular physiology 227, 2323-2329
Kunzelmann, K., Tian, Y., Martins, J. R., Faria, D., Kongsuphol, P., Ousingsawat, J., Wolf, L., and Schreiber, R. (2012) Airway epithelial cells--functional links between CFTR and anoctamin dependent Cl- secretion. The international journal of biochemistry & cell biology 44, 1897-1900
Kunzelmann, K., Schreiber, R., Kmit, A., Jantarajit, W., Martins, J. R., Faria, D., Kongsuphol, P., Ousingsawat, J., and Tian, Y. (2012) Expression and function of epithelial anoctamins. Experimental physiology 97, 184-192
Kunzelmann, K., and Schreiber, R. (2012) Airway epithelial cells--hyperabsorption in CF? The international journal of biochemistry & cell biology 44, 1232-1235
Faria, D., Lentze, N., Almaça, J., Luz, S., Alessio, L., Tian, Y., Martins, J. P., Cruz, P., Schreiber, R., Rezwan, M., Farinha, C. M., Auerbach, D., Amaral, M. D., and Kunzelmann, K. (2012) Regulation of ENaC biogenesis by the stress response protein SERP1. Pflugers Archiv : European journal of physiology 463, 819-827
Duvvuri, U., Shiwarski, D. J., Xiao, D., Bertrand, C., Huang, X., Edinger, R. S., Rock, J. R., Harp, B. D., Henson, B. J., Kunzelmann, K., Schreiber, R., Seethala, R. S., Egloff, A. M., Chen, X., Lui, V. W., Grandis, J. R., and Gollin, S. M. (2012) TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer research 72, 3270-3281
2011
Tian, Y., Kongsuphol, P., Hug, M., Ousingsawat, J., Witzgall, R., Schreiber, R., and Kunzelmann, K. (2011) Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25, 1058-1068
Ousingsawat, J., Mirza, M., Tian, Y., Roussa, E., Schreiber, R., Cook, D. I., and Kunzelmann, K. (2011) Rotavirus toxin NSP4 induces diarrhoea by activation of TMEM16A and inhibition of Na+ absorption. Pflugers Archiv : European journal of physiology 461, 579-589
Ousingsawat, J., Kongsuphol, P., Schreiber, R., and Kunzelmann, K. (2011) CFTR and TMEM16A are separate but functionally related Cl- channels. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 28, 715-724
Martins, J. R., Kongsuphol, P., Sammels, E., Dahimène, S., Aldehni, F., Clarke, L. A., Schreiber, R., de Smedt, H., Amaral, M. D., and Kunzelmann, K. (2011) F508del-CFTR increases intracellular Ca(2+) signalling that causes enhanced calcium-dependent Cl(-) conductance in cystic fibrosis. Biochimica et biophysica acta 1812, 1385-1392
Martins, J. R., Faria, D., Kongsuphol, P., Reisch, B., Schreiber, R., and Kunzelmann, K. (2011) Anoctamin 6 is an essential component of the outwardly rectifying chloride channel. Proceedings of the National Academy of Sciences of the United States of America 108, 18168-18172
Luz, S., Kongsuphol, P., Mendes, A. I., Romeiras, F., Sousa, M., Schreiber, R., Matos, P., Jordan, P., Mehta, A., Amaral, M. D., Kunzelmann, K., and Farinha, C. M. (2011) Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity. Molecular and cellular biology 31, 4392-4404
Kunzelmann, K., Tian, Y., Martins, J. R., Faria, D., Kongsuphol, P., Ousingsawat, J., Thevenod, F., Roussa, E., Rock, J., and Schreiber, R. (2011) Anoctamins. Pflugers Archiv : European journal of physiology 462, 195-208
Kunzelmann, K., Kongsuphol, P., Chootip, K., Toledo, C., Martins, J. R., Almaca, J., Tian, Y., Witzgall, R., Ousingsawat, J., and Schreiber, R. (2011) Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells. Biological chemistry 392, 125-134
Kongsuphol, P., Schreiber, R., Kraidith, K., and Kunzelmann, K. (2011) CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl- conductance. Pflugers Archiv : European journal of physiology 462, 479-487
Faria, D., Dahimène, S., Alessio, L., Scott-Ward, T., Schreiber, R., Kunzelmann, K., and Amaral, M. D. (2011) Effect of Annexin A5 on CFTR: regulated traffic or scaffolding? Molecular membranebiology28, 14-29
2010
Schreiber, R., Uliyakina, I., Kongsuphol, P., Warth, R., Mirza, M., Martins, J. R., and Kunzelmann, K. (2010) Expression and function of epithelial anoctamins. The Journal of biological chemistry 285, 7838-7845
Kongsuphol, P., Cassidy, D., Romeiras, F., Schreiber, R., Mehta, A., and Kunzelmann, K. (2010) Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 25, 389-396
Koehl, G. E., Spitzner, M., Ousingsawat, J., Schreiber, R., Geissler, E. K., and Kunzelmann, K. (2010) Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice. Oncogene 29, 1553-1560
Carota, I., Theilig, F., Oppermann, M., Kongsuphol, P., Rosenauer, A., Schreiber, R., Jensen, B. L., Walter, S., Kunzelmann, K., and Castrop, H. (2010) Localisation and functional characterization of the human NKCC2 isoforms. Acta physiologica (Oxford, England) 199, 327-338
Barro-Soria, R., Aldehni, F., Almaça, J., Witzgall, R., Schreiber, R., and Kunzelmann, K. (2010) ER-localised bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel. Pflugers Archiv : European journal of physiology 459, 485-497
2009
Ousingsawat, J., Martins, J. R., Schreiber, R., Rock, J. R., Harfe, B. D., and Kunzelmann, K. (2009) Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. The Journal of biological chemistry 284, 28698-28703
Milenkovic, V. M., Soria, R. B., Aldehni, F., Schreiber, R., and Kunzelmann, K. (2009) Functional assembly and purinergic activation of bestrophins. Pflugers Archiv : European journal of physiology 458, 431-441
Kunzelmann, K., Kongsuphol, P., Aldehni, F., Tian, Y., Ousingsawat, J., Warth, R., and Schreiber, R. (2009) Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions. Cell calcium 46, 233-241
Kongsuphol, P., Hieke, B., Ousingsawat, J., Almaca, J., Viollet, B., Schreiber, R., and Kunzelmann, K. (2009) Regulation of Cl(-) secretion by AMPK in vivo. Pflugers Archiv : European journal of physiology 457, 1071-1078
Kongsuphol, P., Cassidy, D., Hieke, B., Treharne, K. J., Schreiber, R., Mehta, A., and Kunzelmann, K. (2009) Mechanistic insight into control of CFTR by AMPK. The Journal of biological chemistry 284, 5645-5653
Faria, D., Schreiber, R., and Kunzelmann, K. (2009) CFTR is activated through stimulation of purinergic P2Y2 receptors. Pflugers Archiv : European journal of physiology 457, 1373-1380
Barro Soria, R., Spitzner, M., Schreiber, R., and Kunzelmann, K. (2009) Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia. The Journal of biological chemistry 284, 29405-29412
Almaça, J., Tian, Y., Aldehni, F., Ousingsawat, J., Kongsuphol, P., Rock, J. R., Harfe, B. D., Schreiber, R., and Kunzelmann, K. (2009) TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. The Journal of biological chemistry 284, 28571-28578
Almaça, J., Kongsuphol, P., Hieke, B., Ousingsawat, J., Viollet, B., Schreiber, R., Amaral, M. D., and Kunzelmann, K. (2009) AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated. Pflugers Archiv : European journal of physiology 458, 713-721
Aldehni, F., Spitzner, M., Martins, J. R., Barro-Soria, R., Schreiber, R., and Kunzelmann, K. (2009) Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells. Journal of the American Society of Nephrology : JASN 20, 1556-1564
2008
Spitzner, M., Martins, J. R., Soria, R. B., Ousingsawat, J., Scheidt, K., Schreiber, R., and Kunzelmann, K. (2008) Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells. The Journal of biological chemistry 283, 7421-7428
Schreiber, R., Castrop, H., and Kunzelmann, K. (2008) Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice. Pflugers Archiv : European journal of physiology 457, 431-440
Ousingsawat, J., Spitzner, M., Schreiber, R., and Kunzelmann, K. (2008) Upregulation of colonic ion channels in APC ( Min/+ ) mice. Pflugers Archiv : European journal of physiology 456, 847-855
Milenkovic, V. M., Langmann, T., Schreiber, R., Kunzelmann, K., and Weber, B. H. (2008) Molecular evolution and functional divergence of the bestrophin protein family. BMC evolutionary biology 8, 72
Barro-Soria, R., Schreiber, R., and Kunzelmann, K. (2008) Bestrophin 1 and 2 are components of the Ca(2+) activated Cl(-) conductance in mouse airways. Biochimica et biophysica acta 1783, 1993-2000
Bachhuber, T., Almaça, J., Aldehni, F., Mehta, A., Amaral, M. D., Schreiber, R., and Kunzelmann, K. (2008) Regulation of the epithelial Na+ channel by the protein kinase CK2. The Journal of biological chemistry 283, 13225-13232
2007
Spitzner, M., Ousingsawat, J., Scheidt, K., Kunzelmann, K., and Schreiber, R. (2007) Voltage-gated K+ channels support proliferation of colonic carcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 35-44
Sousa, M., Ousingsawat, J., Seitz, R., Puntheeranurak, S., Regalado, A., Schmidt, A., Grego, T., Jansakul, C., Amaral, M. D., Schreiber, R., and Kunzelmann, K. (2007) An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis. Molecular pharmacology 71, 366-376
Puntheeranurak, S., Schreiber, R., Spitzner, M., Ousingsawat, J., Krishnamra, N., and Kunzelmann, K. (2007) Control of ion transport in mouse proximal and distal colon by prolactin. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 19, 77-88
Ousingsawat, J., Spitzner, M., Puntheeranurak, S., Terracciano, L., Tornillo, L., Bubendorf, L., Kunzelmann, K., and Schreiber, R. (2007) Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research 13, 824-831
Kunzelmann, K., Milenkovic, V. M., Spitzner, M., Soria, R. B., and Schreiber, R. (2007) Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin ? Pflugers Archiv : European journal of physiology 454, 879-889
2006
Kunzelmann, K., Spitzner, M., Ousingsawat, J., Martins, J. R., and Schreiber, R. (2006) Expression of ion channels in colon carcinoma: New diagnostic and therapeutic possibilities? Oncology Today 2, 18-21
Kunzelmann, K., Scheidt, K., Scharf, B., Ousingsawat, J., Schreiber, R., Wainwright, B., and McMorran, B. (2006) Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, 545-546
2005
Schreiber, R., and Kunzelmann, K. (2005) Purinergic P2Y6 receptors induce Ca2+ and CFTR dependent Cl- secretion in mouse trachea. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 16, 99-108
Schreiber, R. (2005) Ca2+ signalling, intracellular pH and cell volume in cell proliferation. The Journal of membrane biology 205, 129-137
Kunzelmann, K., Sun, J., Markovich, D., König, J., Mürle, B., Mall, M., and Schreiber, R. (2005) Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR-2). FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 969-970
Kunzelmann, K., Bachhuber, T., Regeer, R., Markovich, D., Sun, J., and Schreiber, R. (2005) Purinergic inhibition of the epithelial Na+ transport via hydrolysis of PIP2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19, 142-143
unzelmann, K., Bachhuber, T., Adam, G., Voelcker, T., Murle, B., Mall, M., and Schreiber, R. (2005) Role of CFTR and Other Ion Channels in Cystic Fibrosis. in Defects of Secretion in Cystic Fibrosis (Schultz, C. ed., Springer US, Boston, MA
Bachhuber, T., König, J., Voelcker, T., Mürle, B., Schreiber, R., and Kunzelmann, K. (2005) Cl- interference with the epithelial Na+ channel ENaC. The Journal of biological chemistry 280, 31587-31594
Adam, G., Ousingsawat, J., Schreiber, R., and Kunzelmann, K. (2005) Increase in intracellular Cl- concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells. Pflugers Archiv : European journal of physiology 449, 470-478
2004
Schreiber, R., Boucherot, A., Mürle, B., Sun, J., and Kunzelmann, K. (2004) Control of epithelial ion transport by Cl- and PDZ proteins. The Journal of membrane biology 199, 85-98
Schreiber, R., Bartoszyk, G. D., and Kunzelmann, K. (2004) The kappa-opioid receptor agonist asimadoline inhibits epithelial transport in mouse trachea and colon. European journal of pharmacology 503, 185-190
Kunzelmann, K., Sun, J., Schreiber, R., and König, J. (2004) Effects of dietary lectins on ion transport in epithelia. British journal of pharmacology 142, 1219-1226
2003
Schreiber, R., König, J., Sun, J., Markovich, D., and Kunzelmann, K. (2003) Effects of purinergic stimulation, CFTR and osmotic stress on amiloride-sensitive Na+ transport in epithelia and Xenopus oocytes. The Journal of membrane biology 192, 101-110
Oceandy, D., McMorran, B., Schreiber, R., Wainwright, B. J., and Kunzelmann, K. (2003) GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon. The Journal of membranebiology192, 159-167
Mall, M., Gonska, T., Thomas, J., Schreiber, R., Seydewitz, H. H., Kuehr, J., Brandis, M., and Kunzelmann, K. (2003) Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. Pediatric research 53, 608-618
Kottgen, M., Loffler, T., Jacobi, C., Nitschke, R., Pavenstadt, H., Schreiber, R., Frische, S., Nielsen, S., and Leipziger, J. (2003) P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport. The Journal of clinical investigation 111, 371-379
2002
Schreiber, R., Mürle, B., Sun, J., and Kunzelmann, K. (2002) Electrolyte transport in the mouse trachea: no evidence for a contribution of luminal K(+) conductance. The Journal of membrane biology 189, 143-151
Oceandy, D., McMorran, B. J., Smith, S. N., Schreiber, R., Kunzelmann, K., Alton, E. W., Hume, D. A., and Wainwright, B. J. (2002) Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human molecular genetics 11, 1059-1067
Mall, M., Gonska, T., Thomas, J., Hirtz, S., Schreiber, R., and Kunzelmann, K. (2002) Activation of ion secretion via proteinase-activated receptor-2 in human colon. American journal of physiology. Gastrointestinal and liver physiology 282, G200-210
Kunzelmann, K., Schreiber, R., König, J., and Mall, M. (2002) Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. Cell biochemistry and biophysics 36, 209-214
Kunzelmann, K., Schreiber, R., and Cook, D. (2002) Mechanisms for the inhibition of amiloride-sensitive Na+ absorption by extracellular nucleotides in mouse trachea. Pflugers Archiv : European journal of physiology 444, 220-226
König, J., Schreiber, R., Mall, M., and Kunzelmann, K. (2002) No evidence for inhibition of ENaC through CFTR-mediated release of ATP. Biochimica et biophysica acta 1565, 17-28
Kerst, G., Brousos, H., Schreiber, R., Nitschke, R., Hug, M. J., Greger, R., and Bleich, M. (2002) The oxidant thimerosal modulates gating behaviour of KCNQ1 by interaction with the channel outer shell. The Journal of membrane biology 186, 89-100
Boucherot, A., Schreiber, R., Pavenstädt, H., and Kunzelmann, K. (2002) Cloning and expression of the mouse glomerular podoplanin homologue gp38P. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 17, 978-984
2001
Schreiber, R., Kindle, P., Benzing, T., Walz, G., and Kunzelmann, K. (2001) Control of the cystic fibrosis transmembrane conductance regulator by alphaG(i) and RGS proteins. Biochemical and biophysical research communications 281, 917-923
Lambert, G., Becker, B., Schreiber, R., Boucherot, A., Reth, M., and Kunzelmann, K. (2001) Control of cystic fibrosis transmembrane conductance regulator expression by BAP31. The Journal of biological chemistry 276, 20340-20345
Kunzelmann, K., Schreiber, R., and Boucherot, A. (2001) Mechanisms of the inhibition of epithelial Na(+) channels by CFTR and purinergic stimulation. Kidney international 60, 455-461
Kunzelmann, K., Hübner, M., Schreiber, R., Levy-Holzman, R., Garty, H., Bleich, M., Warth, R., Slavik, M., von Hahn, T., and Greger, R. (2001) Cloning and function of the rat colonic epithelial K+ channel KVLQT1. The Journal of membrane biology 179, 155-164
Kunzelmann, K., Bleich, M., Warth, R., Levy-Holzman, R., Garty, H., and Schreiber, R. (2001) Expression and function of colonic epithelial KvLQT1 K+ channels. Clinical and experimental pharmacology & physiology 28, 79-83
König, J., Schreiber, R., Voelcker, T., Mall, M., and Kunzelmann, K. (2001) The cystic fibrosis transmembrane conductance regulator (CFTR) inhibits ENaC through an increase in the intracellular Cl- concentration. EMBO reports 2, 1047-1051
Kerst, G., Beschorner, U., Unsöld, B., von Hahn, T., Schreiber, R., Greger, R., Gerlach, U., Lang, H. J., Kunzelmann, K., and Bleich, M. (2001) Properties and function of KCNQ1 K+ channels isolated from the rectal gland of Squalus acanthias. Pflugers Archiv : European journal of physiology 443, 146-154
Greger, R., Schreiber, R., Mall, M., Wissner, A., Hopf, A., Briel, M., Bleich, M., Warth, R., and Kunzelmann, K. (2001) Cystic fibrosis and CFTR. Pflugers Archiv : European journal of physiology 443 Suppl 1, S3-7
166.boucherot, A., Schreiber, R., and Kunzelmann, K. (2001) Role of CFTR's PDZ1-binding domain, NBF1 and Cl(-) conductance in inhibition of epithelial Na(+) channels in Xenopus oocytes. Biochimica et biophysica acta 1515, 64-71
Boucherot, A., Schreiber, R., and Kunzelmann, K. (2001) Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the cystic fibrosis transmembrane conductance regulator. The Journal of membrane biology 182, 39-47
2000
Unsöld, B., Kerst, G., Brousos, H., Hübner, M., Schreiber, R., Nitschke, R., Greger, R., and Bleich, M. (2000) KCNE1 reverses the response of the human K+ channel KCNQ1 to cytosolic pH changes and alters its pharmacology and sensitivity to temperature. Pflugers Archiv : European journal of physiology 441, 368-378
Schreiber, R., Pavenstädt, H., Greger, R., and Kunzelmann, K. (2000) Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator. FEBS letters 475, 291-295
Mall, M., Wissner, A., Schreiber, R., Kuehr, J., Seydewitz, H. H., Brandis, M., Greger, R., and Kunzelmann, K. (2000) Role of K(V)LQT1 in cyclic adenosine monophosphate-mediated Cl(-) secretion in human airway epithelia. American journal of respiratory cell and molecular biology 23, 283-289
Kunzelmann, K., Schreiber, R., Nitschke, R., and Mall, M. (2000) Control of epithelial Na+ conductance by the cystic fibrosis transmembrane conductance regulator. Pflugers Archiv : European journal of physiology 440, 193-201
Kunzelmann, K., Hübner, M., Vollmer, M., Ruf, R., Hildebrandt, F., Greger, R., and Schreiber, R. (2000) A Bartter's syndrome mutation of ROMK1 exerts dominant negative effects on K(+) conductance. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 10, 117-124
Kim, S. J., Kerst, G., Schreiber, R., Pavenstädt, H., Greger, R., Hug, M. J., and Bleich, M. (2000) Inwardly rectifying K+ channels in the basolateral membrane of rat pancreatic acini. Pflugers Archiv : European journal of physiology 441, 331-340
Han, B., Klonowski-Stumpe, H., Lüthen, R., Schreiber, R., Häussinger, D., and Niederau, C. (2000) Menadione-induced oxidative stress inhibits cholecystokinin-stimulated secretion of pancreatic acini by cell dehydration Pancreas 21, 191-202
Gloy, J., Reitinger, S., Fischer, K. G., Schreiber, R., Boucherot, A., Kunzelmann, K., Mundel, P., and Pavenstädt, H. (2000) Amino acid transport in podocytes. American journal of physiology. Renal physiology 278, F999-f1005
Benzing, T., Yaffe, M. B., Arnould, T., Sellin, L., Schermer, B., Schilling, B., Schreiber, R., Kunzelmann, K., Leparc, G. G., Kim, E., and Walz, G. (2000) 14-3-3 interacts with regulator of G protein signalling proteins and modulates their activity. The Journal of biological chemistry 275, 28167-28172
1999
Warth, R., Hamm, K., Bleich, M., Kunzelmann, K., von Hahn, T., Schreiber, R., Ullrich, E., Mengel, M., Trautmann, N., Kindle, P., Schwab, A., and Greger, R. (1999) Molecular and functional characterisation of the small Ca(2+)-regulated K+ channel (rSK4) of colonic crypts. Pflugers Archiv : European journal of physiology 438, 437-444
Schreiber, R., Nitschke, R., Greger, R., and Kunzelmann, K. (1999) The cystic fibrosis transmembrane conductance regulator activates aquaporin 3 in airway epithelial cells. The Journal of biological chemistry 274, 11811-11816
Schreiber, R., Hopf, A., Mall, M., Greger, R., and Kunzelmann, K. (1999) The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel. Proceedings of the National Academy of Sciences of the United States of America 96, 5310-5315
Niederau, C., Luthen, R., Klonowski-Stumpe, H., Schreiber, R., Soika, I., Sata, N., Bing, H., and Haussinger, D. (1999) The role of calcium in pancreatitis. Hepato-gastroenterology 46, 2723-2730
Kunzelmann, K., and Schreiber, R. (1999) CFTR, a regulator of channels. The Journal of membrane biology 168, 1-8
Köttgen, M., Hoefer, A., Kim, S. J., Beschorner, U., Schreiber, R., Hug, M. J., and Greger, R. (1999) Carbachol activates a K+ channel of very small conductance in the basolateral membrane of rat pancreatic acinar cells. Pflugers Archiv : European journal of physiology 438, 597-603
Hübner, M., Schreiber, R., Boucherot, A., Sanchez-Perez, A., Poronnik, P., Cook, D. I., and Kunzelmann, K. (1999) Feedback inhibition of epithelial Na(+) channels in Xenopus oocytes does not require G(0) or G(i2) proteins. FEBS letters 459, 443-447
Hopf, A., Schreiber, R., Mall, M., Greger, R., and Kunzelmann, K. (1999) Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations. The Journal of biological chemistry 274, 13894-13899
1998
Mall, M., Bleich, M., Greger, R., Schreiber, R., and Kunzelmann, K. (1998) The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. The Journal of clinical investigation 102, 15-21
Kunzelmann, K., Briel, M., Schreiber, R., Ricken, S., Nitschke, R., and Greger, R. (1998) No evidence for direct activation of the cystic fibrosis transmembrane conductance regulator by 8-cyclopentyl-1,3-dipropylxanthine. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 8, 185-193
1997
Schreiber, R., Greger, R., Nitschke, R., and Kunzelmann, K. (1997) Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes. Pflugers Archiv : European journal of physiology 434, 841-847
Kunzelmann, K., Kiser, G. L., Schreiber, R., and Riordan, J. R. (1997) Inhibition of epithelial Na+ currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator. FEBS letters 400, 341-344
Kubitz, R., Schreiber, R., vom Dahl, S., and Häussinger, D. (1997) Ethanol Induces Vesicular Alkalinisation in Rat Hepatocytes Cellular Physiology and Biochemistry 7, 289-297
Klonowski-Stumpe, H., Schreiber, R., Grolik, M., Schulz, H. U., Häussinger, D., and Niederau, C. (1997) Effect of oxidative stress on cellular functions and cytosolic free calcium of rat pancreatic acinar cells. The American journal of physiology 272, G1489-1498
1996
Schreiber, R., Zhang, F., and Häussinger, D. (1996) Regulation of vesicular pH in liver macrophages and parenchymal cells by ammonia and anisotonicity as assessed by fluorescein isothiocyanate-dextran fluorescence. The Biochemical journal 315, 385-392
1995
Zhang, F., Warskulat, U., Wettstein, M., Schreiber, R., Henninger, H. P., Decker, K., and Häussinger, D. (1995) Hyperosmolarity stimulates prostaglandin synthesis and cyclooxygenase-2 expression in activated rat liver macrophages. The Biochemical journal 312, 135-143
Schreiber, R., and Häussinger, D. (1995) Characterisation of the swelling-induced alkalinization of endocytotic vesicles in fluorescein isothiocyanate-dextran-loaded rat hepatocytes. The Biochemical journal 309, 19-24
Schliess, F., Schreiber, R., and Häussinger, D. (1995) Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells. The Biochemical journal 309, 13-17
1994
Schreiber, R., Stoll, B., Lang, F., and Häussinger, D. (1994) Effects of aniso-osmolarity and hydroperoxides on intracellular pH in isolated rat hepatocytes as assessed by (2',7')-bis(carboxyethyl)-5(6)-carboxyfluorescein and fluorescein isothiocyanate-dextran fluorescence. The Biochemical journal 303, 113-120
Häussinger, D., Newsome, W., vom Dahl, S., Stoll, B., Noe, B., Schreiber, R., Wettstein, M., and Lang, F. (1994) Control of liver cell function by the hydration state. Biochemical Society transactions 22, 497-502
Busch, G. L., Schreiber, R., Dartsch, P. C., Völkl, H., Vom Dahl, S., Häussinger, D., and Lang, F. (1994) Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytes. Proceedings of the National Academy of Sciences of the United States of America 91, 9165-9169
1993
Saha, N., Schreiber, R., vom Dahl, S., Lang, F., Gerok, W., and Häussinger, D. (1993) Endogenous hydroperoxide formation, cell volume and cellular K+ balance in perfused rat liver. The B