Publikationen

 

Busch MR, Rajendran C, Sterner R. Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli. Markus R Busch, Chitra Rajendran, Reinhard Sterner Biochemistry. 2023 Feb 7;62(3):863-872. doi: 10.1021/acs.biochem.2c00640. Epub 2023 Jan 4.

Towards Photochromic Azobenzene-Based Inhibitors for Tryptophan Synthase. Simeth NA, Kinateder T, Rajendran C, Nazet J, Merkl R, Sterner R, König B, Kneuttinger AC Chemistry. 2021 Feb 1;27(7):2439-2451. doi: 10.1002/chem.202004061. Epub 2020 Dec 22.

Towards Photochromic Azobenzene-Based Inhibitors for Tryptophan Synthase. Simeth NA, Kinateder T, Rajendran C, Nazet J, Merkl R, Sterner R, König B, Kneuttinger AC. Chemistry. 2021 Feb 1;27(7):2439-2451. doi: 10.1002/chem.202004061. Epub 2020 Dec 22.

Light Regulation of Enzyme Allostery Through Photo-responsive Unnatural Amino Acids. Andrea C Kneutinger, Kristina Straub, Philipp Bittner, Nadja A Simeth, Astrid Bruckmann, Florian Busch, Chitra Rajendran, Enrico Hupfeld, Vicki H Wysocki, Dominik Horinek, Burkhard König, Rainer Merkl, Reinhard Sterner  Cell Chem Biol.26 (11), 1501-1514 Nov 2019 DOI: 10.1016/j.chembiol.2019.08.006 

Mapping the Allosteric Communication Network of Aminodeoxychorismate Synthase. Semmelmann F, Straub K, Nazet J, Rajendran C, Merkl R, Sterner R. J Mol Biol. 2019 May 21. pii: S0022-2836(19)30293-1. doi: 10.1016/j.jmb.2019.05.021.

Library Selection With a Randomized Repertoire of (βα) 8-Barrel Enzymes Results in Unexpected Induction of Gene Expression. Bettina Rohweder, Gerhard Lehmann, Norbert Eichner, Tino Polen, Chitra Rajendran, Fabian     Ruperti, Mona Linde, Thomas Treiber, Oona Jung, Katja Dettmer, Gunter Meister, Michael Bott, Wolfram Gronwald, Reinhard Sterner  Biochemistry 58 (41), 4207-4217

In meso crystal structure of a novel membrane-associated octaheme cytochrome c from the Crenarchaeon Ignicoccus hospitalis. Parey K, Fielding AJ, Sörgel M, Rachel R, Huber H, Ziegler C, Rajendran C►. FEBS J. 2016     Oct;283(20):3807-3820. doi: 10.1111/febs.13870. Epub 2016 Sep 19.

Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes. Busch F, Rajendran C, Heyn K, Schlee S, Merkl R, Sterner R. Cell Chem Biol. 2016 Jun 23;23(6):709-15. doi: 10.1016/j.chembiol.2016.05.009. Epub 2016 Jun 9.

Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases. Safarian S, Rajendran C, Müller H, Preu J, Langer JD, Ovchinnikov S, Hirose T, Kusumoto T, Sakamoto J, Michel H. Science. 2016 Apr 29;352(6285):583-6. doi: 10.1126/science.aaf2477.

Using Strictosidine Synthase to Prepare Novel Alkaloids.
 Zhu H, Kerčmar P, Wu F, Rajendran C, Sun L, Wang M, Stöckigt J. Curr Med Chem. 2015 Apr 8. [Epub ahead of print]

Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization. Chiu E, Hijnen M, Bunker RD, Boudes M, Rajendran C, Aizel K, Oliéric V, Schulze-Briese C, Mitsuhashi W, Young V, Ward VK, Bergoin M, Metcalf P, Coulibaly F. Proc Natl Acad Sci USA. 2015 Mar 31;112(13):3973-8. doi: 10.1073/pnas.1418798112. Epub 2015 Mar 18.

Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.
Dong J, Zhao H, Zhou T, Spiliotopoulos D, Rajendran C, Li XD, Huang D, Caflisch A. ACS Med Chem Lett. 2014 Sep 29;6(1):79-83. doi: 10.1021/ml500355x. eCollection 2015 Jan 8.

TrpB2 enzymes are O-phospho-l-serine dependent tryptophan synthases. Busch F, Rajendran C, Mayans O, Löffler P, Merkl R, Sterner R. Biochemistry. 2014 Sep 30;53(38):6078-83. doi: 10.1021/bi500977y. Epub 2014 Sep 17.

Ligand structures of synthetic deoxa-pyranosylamines with raucaffricine and strictosidine glucosidases provide structural insights into their binding and inhibitory behaviours. Xia L, Lin H, Staniek A, Panjikar S, Ruppert M, Hilgers P, Williardt J, Rajendran C, Wang M, Warzecha H, Jäger V, Stöckigt J. J Enzyme Inhib Med Chem. 2015 Jun;30(3):472-8.

A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization. Peterhoff D, Beer B, Rajendran C, Kumpula EP, Kapetaniou E, Guldan H, Wierenga RK, Sterner R, Babinger P. Mol Microbiol. 2014 May;92(4):885-99. doi: 10.1111/mmi.12596. Epub 2014 Apr 16.

Evidence for the existence of elaborate enzyme complexes in the Paleoarchean era. Reisinger B, Sperl J, Holinski A, Schmid V, Rajendran C, Carstensen L, Schlee S, Blanquart S, Merkl R, Sterner R. J Am Chem Soc. 2014 Jan 8;136(1):122-9. doi: 10.1021/ja4115677. Epub 2013 Dec 23.

Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template. Meier MM, Rajendran C, Malisi C, Fox NG, Xu C, Schlee S, Barondeau DP, Höcker B, Sterner  R, Raushel FM. J Am Chem Soc. 2013 Aug 7;135(31):11670-7. doi: 10.1021/ja405911h. Epub 2013 Jul 29.

Establishing catalytic activity on an artificial (βα)8-barrel protein designed from identical half-barrels. Sperl JM, Rohweder B, Rajendran C, Sterner R. FEBS Lett. 2013 Sep 2;587(17):2798-805. 

A sugar isomerization reaction established on various (βα)₈-barrel scaffolds is based on substrate-assisted catalysis. Reisinger B, Bocola M, List F, Claren J, Rajendran C, Sterner R. Protein Eng Des Sel. 2012 Nov;25(11):751-60. 

High speed X-ray analysis of plant enzymes at room temperature.
Xia L, Rajendran C, Ruppert M, Panjikar S, Wang M, Stoeckigt J. Phytochemistry. 2013 Jul;91:88-92. 

Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding. Sun L, Chen Y, Rajendran C, Mueller U, Panjikar S, Wang M, Mindnich R, Rosenthal C, Penning TM, Stöckigt J. J Biol Chem. 2012 Mar 30;287(14):11213-21. 

Scaffold tailoring by a newly detected Pictet-Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework. Wu F, Zhu H, Sun L, Rajendran C, Wang M, Ren X, Panjikar S, Cherkasov A, Zou H, Stöckigt J. J Am Chem Soc. 2012 Jan 25;134(3):1498-500. 

Crystal structure of the GlnZ-DraG complex reveals a different form of PII-target interaction.
Rajendran C, Gerhardt EC, Bjelic S, Gasperina A, Scarduelli M, Pedrosa FO, Chubatsu LS, Merrick M, Souza EM, Winkler FK, Huergo LF, Li XD. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18972-6. 

Structures of alkaloid biosynthetic glucosidases decode substrate specificity.
Xia L, Ruppert M, Wang M, Panjikar S, Lin H, Rajendran C, Barleben L, Stöckigt J. ACS Chem Biol. 2012 Jan 20;7(1):226-34. 

Radiation damage in room-temperature data acquisition with the PILATUS 6M pixel detector.
Rajendran C, Dworkowski FS, Wang M, Schulze-Briese C. J Synchrotron Radiat. 2011 May;18(Pt 3):318-28. doi: 10.1107/S090904951100968X. Epub 2011 Apr 9.

Structure at 1.5 A resolution of cytochrome c(552) with its flexible linker segment, a membrane-anchored protein from Paracoccus denitrificans.
Rajendran C, Ermler U, Ludwig B, Michel H. Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):850-4. 

The atomic structure of baculovirus polyhedra reveals the independent emergence of infectious crystals in DNA and RNA viruses.
Coulibaly F, Chiu E, Gutmann S, Rajendran C, Haebel PW, Ikeda K, Mori H, Ward VK,  Schulze-Briese C, Metcalf P. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22205-10. 

Structure at 1.3 A resolution of Rhodothermus marinus caa(3) cytochrome c domain. Srinivasan V*, Rajendran C*, Sousa FL, Melo AM, Saraiva LM, Pereira MM, Santana M, Teixeira M, Michel H. J Mol Biol. 2005 Feb 4;345(5):1047-57. Epub 2004 Dec 7.

* equally contributed first author / # corresponding author